Don't let the bedbugs bite.
But if they do.
Beat them 'til they're black and blue.
Better yet, follow the advice contained in this article in the Wall Street Journal:
Use the luggage rack for your suitcase, and keep the suitcase off the floor or an extra bed. Don't put clothes in the hotel dresser or drape them on hotel furniture. Consider setting your suitcase on the bathroom counter, where it's less likely bugs will be.
Inspect the entire bed area. That means pulling off the fitted sheets and searching the crevasses of mattress sides, box springs, the headboard and nightstand. Look for adult bed bugs and also dark smears of blood or fecal matter that these insects typically leave behind.
If you find evidence of bedbugs, call hotel management immediately and request a different room.
When you get home, immediately wash your clothes in hot water and dry them on high heat. Don't let them sit in the hamper. Some duffel bags can be heated in the dryer to kill bugs that could be lurking. Carefully inspect suitcases; it might be best to keep them in the garage to make sure nothing gets into the house.
Wortwhile reading even for occasional travelers.